Adverse events may also be reported to the USDA Center for Veterinary Biologics at (1-80) or through the agency’s web site. Veterinarians should report all adverse reactions to the vaccine’s manufacturer. Other systemic adverse reactions have been anecdotally reported. Systemic adverse reactions (such as urticaria, purpura hemorrhagica colic or anaphylaxis) can also occur. Severe reactions at sites of injection can be particularly troublesome, requiring prolonged treatment and convalescence. After receiving a vaccine(s) intramuscularly, some horses experience local muscular swelling and soreness or transient, self-limiting signs including fever, anorexia and lethargy.
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